PostDoc - Data analysis

Centro Nacional de Análisis Genómico

Barcelona, Spain

 

Description

 

The CNAG (www.cnag.eu) started operating in March 2010 with a park of twelve second generation DNA sequencers supported by an extensive informatics infrastructure, becoming one of the major Genome Sequencing Centers in Europe. The CNAG is actively involved in collaborative research projects on a number of specific topics: Disease Gene Identification, Cancer Genomics, Genomics of Infectious Diseases, Model Organism Genomics and Synthetic Biology Genomics of Model Organisms. In addition, we participate in several consortia of networked projects such as the International Cancer Genome Consortium and EU-funded projects such as RD-CONNECT, READNA, AIRPROM, SYBARIS, ESGI and BLUEPRINT. We seek a postdoctoral analyst with a strong computational background to develop, maintain and operate data analysis pipelines at CNAG. The successful applicant will be closely involved with the RD-Connect project (www.rd-connect.eu), in the roles of data analysis and interpretation. The analyst will report to the Bioinformatics Analysis Group Leader and must be able to work independently on his/her specific tasks and as part of a team integrating a system.

 

Investigador - Separación celular, Cultivo, Criopreservación/descongelación

Universidad de Córdoba

Córdoba, Spain

 

Descripción: 

 

Separación celular; Cultivo de células mesenquimales; Criopreservación/descongelación de células; Citometría de flujo; Extracción de DNA, RNA; Diferenciación celular; Inmunocitoquímica convencional y de fluorecencia; Estudios experimentales "in vivo".  

 

Requisitos:

 

Formación posdoctoral  superior a  6 años, reglada y documentada, en Investigación Biomédica, preferiblemente en el área de células madre y  medicina regenerativa.

Estancia posdoctoral en un centro extranjero (mínimo 18 meses), en actividades preferiblemente relacionadas con la medicina regenerativa.

Acreditación oficial, como personal para llevar a cabo procedimientos en animales de experimentación (Categoría B) y como personal encargado de dirigir y diseñar los procedimientos (Categoría C).

Conocimientos de citometría de flujo.

Conocimientos de biología celular y molecular

Experiencia en manejo de animales de laboratorio.

Conocimientos de técnicas de cirugía en experimentación animal.

Experiencia en aplicación de terapia celular a animales de experimentación.

Experiencia en cultivos de células derivadas de médula ósea.

Experiencia en  inmunocitoquímica e inmunohistoquímica convencional y de fluorescencia.

Experiencia en análisis histológico.

Amplios conocimientos en microscopía óptica, confocal y electrónica.

Experiencia en técnicas de microdisección por láser y secuenciación génica.

Experiencia en: cultivos celulares, criopreservación y vitrificación celular, ensayos de migración, citometría de flujo, técnicas de transfección celular.

Conocimiento del idioma Inglés: nivel alto (hablado y escrito). Nivel de comprensión de textos científicos: alto.

Informática: Conocimientos en Técnicas de Imagen aplicadas a Biología celular, Bioestadística y programas de morfometría celular.

Participación en ensayos clínicos y/o proyectos de investigación  de Terapia Celular.

Capacidad para dirigir proyectos de investigación: Haber dirigido al menos un proyecto de investigación.

Capacidad de comunicación oral y escrita: Experiencia en presentación de resultados de forma oral y escrita en foros nacionales e internacionales.

 

PostDoc - Neuroscience 2 positions

Instituto de Neurociencias de Alicante

Alicante, Spain

 

Description:

 

We are looking for postdoctoral scientists to join our multidisciplinary team investigating cellular and molecular mechanisms controlling the development of inhibitory circuits in the cerebral cortex. Candidates should hold a PhD in neuroscience.

 

-1 postdoctoral position for candidates with background in electrophysiology. Candidates with background in electrophysiology in vivo are particularly encouraged to apply.

 

-1 postdoctoral position for candidates with  background in Molecular Biology. A good understanding of microarray analysis, cell sorting, biochemistry, cell biology, DNA technology and/or knowledge in genetic manipulation are desirable.

 

The successful applicants are expected to contribute to the analysis of genes involved in neuronal circuit function using loss and gain of function strategies combined with optogenetics in mice.

More information:

 

Funding is available for an initial period of two years, with salary according to experience.  Applications will be considered until October 15th. Applicants should send an email to Beatriz Rico (brico@umh.es) including: (1) Motivation letter (2) CV, with a separate list of publications; and (3) contact information of two persons from whom references could be requested.

PhD - Structural Genomics

Centro Nacional de Análisis Genómico

Barcelona

Description:

The CNAG started operating in March 2010 with a park of twelve second generation DNA sequencers supported by an extensive informatics infrastructure, becoming one of the major Genome Sequencing Centers in Europe. The CNAG is actively involved in collaborative research projects on a number of specific topics: Disease Gene Identification, Cancer Genomics, Genomics of Infectious Diseases, Model Organism Genomics and Synthetic Biology Genomics of Model Organisms. In addition, we participate in several consortia of networked projects such as the International Cancer Genome Consortium (www.icgc.org), and EU-funded projects such as READNA, AIRPROM, SYBARIS, ESGI and BLUEPRINT.

The CNAG seeks a talented young student with a strong background in bioinformatics for the Structural Genomics Team working on comparative docking for target identification in Tuberculosis. This post is funded by a Plan Nacional of the MINECO. The successful candidate will report to the Genome Biology Group Leader.

Responsibilities:

- Development and implementation of a comparative docking software

- Describe the genome-wide maps of ligand-target interaction in Tuberculosis

Requirements:

- Bachelors degree in Bioinformatics of a related field, Computer Science would be a plus.

- Demonstrated experience in Bioinformatics analysis for comparative docking.

- Master in Bioinformatics would be a plus.

- Average qualification >2.0 (Spanish System).

Applications:

Interested candidates may submit a CV and a brief statement of experience and interests in English before August, 19th 2012 to the following email address borsadetreball@pcb.ub.cat indicating the offer reference in the message subject.

PhD - MicroRNAs in cell death and survival fate

Instituto de Investigación Biomédica.

Universidad de Lleida

Description:

The Pharmacology Unit of the Dept. of Experimental Medicine, Institut de Recerca Biomèdica de Lleida, University of Lleida, Catalonia, invites applications for a doctoral position to study the role of MicroRNAs in cell life and death regulation. The candidate will be involved in a 3 years project under the supervision of Dr. Ribas who is the head leader of “regulation of the cell death by non-coding RNAs (ncRNAs)” team.

Profile:

Candidates should possess a master degree in Life Sciences and be willing to initiate their Ph.D studies. Successful candidates will be guided in the application to a government Fellowship (see below: Appendix A and B). Applicants should be highly motivated students willing to take on intellectual, scientific and technical challenges. English is meant to be the communication language in the lab.

PostDoc - Cancer Epigenetics and Biology Programme

Bellvitge Biomedical Research Institute

Barcelona

Description:

A Postdoctoral Contract is offered in the Chromatin and Disease Group (led by Dr. Esteban Ballestar) within the Cancer Epigenetics and Biology Programme (PEBC) at the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona. Research in the laboratory focuses in epigenetic deregulation mechanisms in the immune system, particularly in the context of autoimmune disease and different differentiation models relevant to immune-related disease [Javierre et al. (2010) Genome Res. 20, 170-179; Ballestar (2011) Nature Reviews Rheumatology 7, 263-271; Rodriguez-Ubreva et al. (2012) Nucleic Acids Research 40, 1954-1968]. The Chromatin and Disease Group (PEBC, IDIBELL) has recently been awarded with a FP7 EU grant for the integration of next-generation sequencing (NGS) data using an immune system model. The project joins efforts from eleven international and multidisciplinary labs and
companies to create the bioinformatics and biostatistical framework for the integrative analysis of NGS, proteomics and metabolomics data. We are seeking for an enthusiastic researcher with strong background in both generation and bioinformatic analysis of high-throughput epigenomics/miRNA expression data.

Requirements:

- PhD degree in Biology, Molecular Biology, Genetics or related.

- Strong background in bioinformatic analysis of high-throughput DNA methylation, ChIP-on-chip and/or ChIP-seq data.
- Advanced English Level.

PhD - Metabolismo y Terapia Génica, IDIBELL-UB

Universidad de Barcelona. Facultad de Medicina

Tesis doctoral en el Grupo de Metabolismo y Terapia Génica, IDIBELL-UB

Description:

We focus on the study of PEPCK isozymes and their role in obesity, diabetes and cancer, using: (i) gene modified models (DNA and siRNA delivery in vivo), (ii) molecular biology and metabolic profiling, and (iii) cell physiology, including the analysis of mitochondrial function.

Currently, the laboratory has a vacant to work in the following active project:

study the role of mitochondrial PEPCK in the liver, muscle and proliferating cells adapted to specific nutrients.

Microscopía de fluorescencia

IMDEA Nanociencia, Cantoblanco, Madrid

Se ofrece contrato de doctorado en microscopía de fluorescencia de moléculas individuales y de súper-resolución óptica. El objetivo del proyecto es desarrollar nuevos métodos de microscopía óptica de súper-resolución aplicados a ADN. Concretamente, el doctorando construirá y caracterizará nanomateriales de ADN fluorescentes usando microscopía de fluorescencia de moléculas individuales y microscopía de fuerza atómica. También estudiará las propiedades fotofísicas de estos materiales usando varias técnicas espectroscópicas. Los nuevos métodos de súper-resolución que se desarrollen se aplicarán al estudio de la estructura de los cromosomas. El enfoque del proyecto será flexible en función de la experiencia y los intereses del doctorando. El proyecto se llevará a cabo en el Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), una institución dinámica, multidisciplinar e internacional en el Campus de Cantoblanco en Madrid.