PhD - Biophysical Chemistry / Soft Matter Physics

CIC biomaGUNE

San Sebastian, Spain

 

Description

 

CIC biomaGUNE is a young and dynamic center for research on biomaterials at the highest level, which offers excellent working conditions and is well equipped with state-of-the-art instrumentation and facilities. In this project, the PhD fellow will create and characterize model systems of the nuclear pore permeability barrier using biochemical, surface science and soft matter physics methods, to better understand how macromolecules are selectively shuttled into and out of the nucleus of living cells. The nuclear pore complex (NPC) is the gateway for the transport of DNA, proteins and other macromolecules between the nucleus and the cytosol of living cells. Selective transport is afforded by a network of specialized polymers (FG-nucleoporins) that fill the 40 nm wide NPC channel. To understand how selective transport in this natural nanoscale sorting device is regulated, nanoscale model systems will be developed, in which FG-nucleoporins are re-assembled on surfaces and in artificial pores. The successful candidate will be given the opportunity to explore different methodological approaches including modern methods of surface functionalization, techniques for the nanoscale characterization of self-assembled soft matter systems (incl. QCM-D, ellipsometry, atomic force microscopy and fluorescence microscopy) and theoretical approaches for rationalizing their behavior. The results of this study may in the future be useful for the development of smart filtering devices or for biotechnological applications such as gene delivery. The PhD project is part of a broader effort in the Richter Group, funded through an ERC Starting Grant, to understand and exploit the working principles of biomolecular hydrogels. The research team is multidisciplinary. The Richter Group combines novel approaches of surface biofunctionalization and a toolbox of state-of-the-art analytical techniques to create biomimetic supramolecular architectures, for the study of fundamental biological questions and for biotechnological applications.

 

PostDoc - Data analysis

Centro Nacional de Análisis Genómico

Barcelona, Spain

 

Description

 

The CNAG (www.cnag.eu) started operating in March 2010 with a park of twelve second generation DNA sequencers supported by an extensive informatics infrastructure, becoming one of the major Genome Sequencing Centers in Europe. The CNAG is actively involved in collaborative research projects on a number of specific topics: Disease Gene Identification, Cancer Genomics, Genomics of Infectious Diseases, Model Organism Genomics and Synthetic Biology Genomics of Model Organisms. In addition, we participate in several consortia of networked projects such as the International Cancer Genome Consortium and EU-funded projects such as RD-CONNECT, READNA, AIRPROM, SYBARIS, ESGI and BLUEPRINT. We seek a postdoctoral analyst with a strong computational background to develop, maintain and operate data analysis pipelines at CNAG. The successful applicant will be closely involved with the RD-Connect project (www.rd-connect.eu), in the roles of data analysis and interpretation. The analyst will report to the Bioinformatics Analysis Group Leader and must be able to work independently on his/her specific tasks and as part of a team integrating a system.

 

PhD - Epigenetic control - 2 vacancies

Centro de Genómica y Oncología, GENyO

Granada, Spain

 

Descripción

 

La Fundación Pública Andaluza Progreso y Salud, entidad central de apoyo y gestión de la investigación, dependiente de la Consejería de Salud y Bienestar Social de la Junta de Andalucía, precisa incorporar para el Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica y Oncología (GENyO), ubicado en Granada, para dar apoyo en el desarrollo del proyecto “EPIPLURIRETRO: Epigenetic control and impact of mammalian retrotransposons in pluripotent genomes.” cuyo investigador principal es el Dr. José Luis García Pérez y financiado por el European Research Council (ERC), a 2 Investigadores/as predoctorales.  La investigación se centra en establecer una relación entre los elementos móviles del ADN, concretamente los retrotransposones Line-1, (hasta hace poco considerados ADN basura) y determinados mecanismos epigenéticos que, según el científico, son capaces de incidir en el movimiento de dichos elementos, controlando su posición e incluso su expresión en mamíferos. Este proyecto se enmarca en la línea de investigación que viene desarrollando el grupo de investigación del Dr. Jose Luis García Pérez y que tiene por objetivo conocer la biología del elemento Line-1, cuya movilidad se relaciona con un amplio rango de enfermedades (cáncer, hemofilia, distrofia muscular, etc.). En este sentido, su grupo de investigación desarrolla varios proyectos para analizar los mecanismos que regulan su movilidad y la variación que se genera a nivel embrionario, para estudiar cómo estos elementos afectan al genoma humano y, más concretamente, a las células madre pluripotentes humanas (aquellas capaces de originar otro tipo de tejido o célula), así como su incidencia en otros tejidos somáticos humanos. Los investigadores trabajaran en los siguientes objetivos:

 

PostDoc - Neuroscience 2 positions

Instituto de Neurociencias de Alicante

Alicante, Spain

 

Description:

 

We are looking for postdoctoral scientists to join our multidisciplinary team investigating cellular and molecular mechanisms controlling the development of inhibitory circuits in the cerebral cortex. Candidates should hold a PhD in neuroscience.

 

-1 postdoctoral position for candidates with background in electrophysiology. Candidates with background in electrophysiology in vivo are particularly encouraged to apply.

 

-1 postdoctoral position for candidates with  background in Molecular Biology. A good understanding of microarray analysis, cell sorting, biochemistry, cell biology, DNA technology and/or knowledge in genetic manipulation are desirable.

 

The successful applicants are expected to contribute to the analysis of genes involved in neuronal circuit function using loss and gain of function strategies combined with optogenetics in mice.

More information:

 

Funding is available for an initial period of two years, with salary according to experience.  Applications will be considered until October 15th. Applicants should send an email to Beatriz Rico (brico@umh.es) including: (1) Motivation letter (2) CV, with a separate list of publications; and (3) contact information of two persons from whom references could be requested.

PostDoc - Molecular biology

Campus de Excelencia Internacional Moncloa-UCM

Madrid

 

We are looking for candidates to apply to current International Call of Post-Doctoral Contracts in the Moncloa Campus of International Excellence (Madrid, Spain).  Candidate would incorporate to the project “Detection of allergenic nuts in foodstuffs using recombinant

peptides and antibodies, and gene probes”. Experience on molecular biology, preferably on recombinant antibodies and multiplex real-time PCR is required.

 

The eligibility criteria for candidates are, according to the call:

(http://www.campusmoncloa.es/es/convocatorias/picata/convocatoria-internacional-contratos-postdoctorales-2012.php)

 

a) To have obtained a doctorate qualification during the eight years prior to the date of the publication of the offer.

b) To provide proof of the contribution made by his/her previous scientific activity: to have at least six articles published in JCR journals.

c) To have participated in at least one competitive research project at a university, research centre or institute, or company or industry.

d) To be under 40 years of age at the time the offer is published.

e) To meet at least one of the following mobility requirements:

 

• Researchers who meet the Marie Curie Programme mobility conditions under the current European Commission Framework Programmes (ie Researchers must not have made a major activity research in Spain for more than 12 months in the last three years).

• Researchers of non-Spanish nationality who have obtained their doctorate outside of Spain.

• Researchers of any nationality who have carried out their research in a country other than that of their nationality for at least 2 years.

 

PostDoc - Computational Systems Biologist

Institute for Research in Biomedicine

Barcelona, Spain

Applications are invited for a postdoctoral position in the Structural Bioinformatics & Network Biology Group (Principal Investigator Prof. Patrick Aloy) at the Institute for Research in Biomedicine (IRB). The successful candidate will work in computational systems biology, more precisely, in the integration of different types of biological data (mainly from proteomics and metabolomics) to build functional models of stem cell aging. The position is associated to a recently funded EU FP7 project, SyStemAge, which aims at understanding age-associated functional alterations in somatic stem cells and their microenvironment. In particular, we intend to apply integrative systems biology approaches to characterize the molecular players, genes and pathways that are associated with physiological processes of ageing and age-related disorders, such as MDS and B-CLL. Finally, we will exploit the resulting models of ageing to develop novel, molecular targeted strategies to treat age-related diseases.

Candidates should be highly motivated, enthusiastic about science, with an ability to think creatively and work independently. The applicant should have a good background in cell and molecular biology, with reasonable exposure to protein interactions and omics technologies. He or she should also have good computing skills and programming/scripting experience. Previous experience with handling large-scale biological data would be an asset.

To apply, please send a cover letter summarizing your past experience, research interests and career goals and CV including the names and contact information of 2-3 references.

Via email to: irbjobs@irbbarcelona.org (Ref.: PostdocCompSysBio PD/12/06)

Websites: sbnb.irbbarcelona.org ; www.irbbarcelona.org

PhD - Evolución genómica de los mamíferos

Universitat Autònoma de Barcelona

Barcelona

Se buscan candidatos para la solicitar una beca pre-doctoral FI-DGR2013 (Generalitat de Catalunya) para la realización de una tesis doctoral en el grupo de Genómica Animal de la UAB. La investigación se realizará en un proyecto internacional (colaboración entre España, Sudáfrica y Australia) enfocado en el estudio de la evolución genómica de los mamíferos. El estudio incluye la aplicación de técnicas de bioinformática, genómica, biología celular, cultivos celulares, microscopía óptica y confocal.

Requisitos:

•Licenciatura en Biología, Biotecnología o Bioquímica

•CV competitivo con un expediente académico igual o superior a 2,5

•Poseer título de master acabado entre el 1 de enero del 2010 y el 31 de diciembre del 2012

•Conocimientos de Inglés

Información complementaria de la oferta y entrega de CV y expediente académico:

Dra. Aurora Ruiz-Herrera Moreno E-mail: aurora.ruizherrera@uab.cat

Web del grupo: http://grupsderecerca.uab.cat/evolgenom/

Información sobre las condiciones de la beca:

http://www10.gencat.cat/agaur_web/AppJava/catala/a_beca.jsp?categoria=predoctorals&id_beca=19041

Fecha límite de entrega de de CV y expediente académico: 6 de Septiembre del 2012.