GlaxoSmithKline I+D SL
Tres Cantos, Madrid, Spain
Description
GlaxoSmithKline I+D SL is seeking an experienced researcher (ER) holding a PhD (or equivalent) in Chemistry or Life Sciences for a 2-year post-doctoral position, who will be supported by the ParaMet Initial Training Network (http://www.paramet.eu/) funded by the EC Marie Curie Program. ParaMet is composed of 11 leading European laboratories in Parasitology from both public and private sectors. This ITN will train a novel generation of scientists in modern biology of protozoan parasite. The selected applicant will attend technical training courses in the different partner laboratories together with the other trainees of the network, will participate in the network meetings and will conduct part of his/her research in partner laboratories. GlaxoSmithKline has recently initiated collaborative activities in the area of drug discovery against diseases caused by trypanosomes and Leishmania. This is predicted to generate hits that will be candidates for further development. After resynthesis of the selected hits, a variety of assays will be performed to characterize the mode of action of active compounds, testing a panel of trypanosomal enzymes from specific metabolic pathways and human counterparts. This analysis will also include studies on intracellular forms of the parasite and, when pertinent, the participation of the host cell in drug mode of action will be assessed. If valuable compounds were identified as suitable for development, the chemical tractability of chemical series would be assessed by an exploratory chemistry effort and pharmacological profiling of ADMET liabilities.
Research Objectives
1. To validate the hits from a compound screening campaign through a panel of phenotypic, as well as target- and pathway-based assays.
2. To prosecute a hit expansion effort by analogue searching, chemoinformatics and exploratory chemistry.
3. To conduct chemical biology experiments aiming at the identification of molecular mode of action and drug target.
Requirements
1. Nationality: Applicants may be a national of a Member State of the European Union, of an Associated Country or of any other third country.
2. Mobility: At the time of selection, the successful candidate must not have resided or carried out his/her main activity in Spain for more than 12 months in the 3 years immediately prior to his/her appointment. Short stays such as holidays are not taken into account.
3. At the time of recruitment, the successful candidate must be in possession of a doctoral degree or have at least four years of full-time equivalent research experience. In both cases, they should have less than 5 years of full‐time equivalent research experience at the time of appointment.
More information and applications
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