PhD - Chronic mental illness

Universidad de Santiago de Compostela

Santiago de Compostela, Spain

Closing date: 22nd February 2014.

Description

Exploring the DISC1-VGF connection in chronic mental illness One ESR Marie S. Curie training position is available at the CIMUS Biomedical Research Institute, University of Santiago de Compostela, Spain (www.usc.es/cimus), in the team of Jesús R. Requena, as part of the Marie S. Curie Initial Training Network (ITN) InSens: (www.in-sens.eu).

Responsibilities and tasks:

The broad picture of the ITN in which this research project is embedded is to establish the molecular foundations of chronic mental illness (CMI) by elucidating the molecular mechanisms of the DISC1 pathway (Korth, 2012, Prion 6:134-41). DISC1, a protein that is truncated in a Scottish family with a high prevalence of CMI, forms insoluble aggregates in a subset of cases of mental disease (Leliveld et al. 2008, J Neurosci 28:3839-45). Following these studies, we have recently discovered that DISC1 regulates the expression of VGF, a neuropeptide precursor with potent antidepressant and neurotrophic properties (manuscript submitted). Therefore, we hypothesize that some of the roles of DISC1 deficits in mental disease might be mediated by reduced expression of VGF. In this context, we aim at investigating the molecular biology of this new member of the extended DISC1 pathway using a variety of molecular, cellular and animal tools, in close collaboration with the other groups that participate in this ITN. In particular, the applicant is expected to carry out studies to elucidate the signalling pathways connecting DISC1 and VGF, to identify VGF receptors and develop receptor agonists, and to study the effect of VGF-derived peptides and VGF receptor agonists on behavioural deficits of DISC1-deficient mouse models.

Requirements

In compliance with Marie S. Curie rules, candidates can only have stayed in the country of application (Spain in this case) a maximum of 12 months in the 3 years prior to enrolment. At the date of appointment, candidates must have obtained, or finalize within 3 months, a Master's (M.Sc.) degree in Biochemistry, Molecular Biology or a similar area.

Hands-on experience in molecular biology and protein biochemistry is desirable, although not mandatory. A strong motivation to pursue a career in science will be positively valued. Solid written and oral communication skills in English are prerequisites of any successful application.

•       Master’s degree in any area of the biosciences.

•   Previous lab experience in protein biochemistry, molecular biology desirable, but not mandatory.

•       A good command of English language.

More information and applications

Please send application letter and cv before Feb. 22, 2014 to: jesus.requena@usc.es